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Supporting Lewy Body Disease Research in Pursuit of a Cure

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LBD Research at Stanford

This is an exciting time for Lewy body dementia (LBD) research in the quest to find a cure. We are proud to support Stanford Medicine; grateful for its sustained commitment and integrated approach to dementia research, from bench to bedside. Dr. Kathleen Poston, her Stanford colleagues, and their collaborators worldwide, are making progress to identify novel markers for LBD. Early and accurate diagnosis will one day become a reality, paving the way for treatment and a cure. The Sue Berghoff LBD Research Fellowship was established to honor the wish of our co-founder, the late Sue Berghoff, that more funding and resources be devoted to focused research, on behalf of all who are living with LBD, until there's a cure.

2023 Research update

Sue Berghoff LBD Research Fellowship

Dr. Carla Abdelnour

Dr. Carla Abdelnour

Dr. Carla Abdelnour

Dr. Carla Abdelnour conducted research as a Sue Berghoff LBD Research Fellow under the mentorship of Prof. Kathleen Poston at Stanford (2022-2024). Carla focused on developing novel markers of Lewy body dementia. In 2025 she began work as a clinician-scientist in the Memory Unit at Institut de  Recerca at Sant Pau, Barcelona


"In recent years, novel techniques have been developed for  identification of potential biomarkers in neurodegenerative diseases," Dr. Abdelnour said. "We are levering this knowledge to study different proteins in blood, CSF, and PET imaging, in combination with clinical and neuropsychological data, to identify new biomarkers for diagnosis and prognosis in Lewy body disease. This will help us understand underlying causes, detect potential therapeutic targets, and improve diagnosis of Lewy body disease patients in clinic."  


A neurologist and researcher, Dr. Abdelnour is investigating the impact of different comorbidities in the clinical presentation, cognitive profile, and disease progression of LBD, and studying the biological underpinnings of prodromal Lewy body disease to identify biomarkers for diagnosis. She holds a medical degree from Central University of Venezuela, and completed her neurology residency at University Hospital Príncipe de Asturias in Spain. She conducted her doctorate in Medicine at the Autonomous University of Barcelona working with Drs. Dag Aarsland, Javier Pagonabarraga and Jaime Kulisevsky. Her thesis focused on the influence of Alzheimer´s disease copathology in atrophy patterns, longitudinal cognitive decline, and heterogeneity of patients with dementia with Lewy bodies.

RESEARCH UPDATE

Dr. Joseph Winer

Dr. Carla Abdelnour

Dr. Carla Abdelnour

Dr. Joseph Winer conducted research into sleep and cognitive trajectories in aging and neurodegenerative diseases in Mormino Lab at Stanford, supported by the mentorship of Prof. Kathleen Poston (2021-2023). Currently he is an Instructor, Neurology & Neuroscience, Stanford.   


According to Dr. Winer, “We are looking at the relationships between data from four research areas: cognitive and behavioral assessments, brain imaging, blood and cerebrospinal fluid samples, and sleep-wake actigraphy measures. A common symptom of Lewy body dementia is fluctuating cognition, behavior, and activity, which can change from moment to moment, hour to hour, or throughout a 24-hour cycle. Understanding the cause of these fluctuations will help us to better understand Lewy body dementia onset and progression to support discovery and development of treatments and ultimately, to find a cure.”      


For his PhD at the University of California at Berkeley, Dr. Winer combined sleep physiology measures with molecular brain imaging in order to investigate how specific markers of sleep disruption are related to changes in the brain in healthy older adults. Based on his background in sleep research, Dr. Winer will also examine how disrupted sleep and daytime function may worsen symptoms of Lewy body dementia.

RESEARCH UPDATE

Dr. Kathleen Poston, MD, MS

Kathleen L. Poston is  the Edward F. and Irene Thiele Pimley Professor of Neurology and Neurological Sciences, and Professor by Courtesy, of Neurosurgery, at Stanford University.  She is Vice-Chair for Research, Department of Neurology & Neurological Sciences, and Chief of the Movement Disorders Division and holds an appointment in the Memory Disorders division. She is a founding member of the Stanford ADRC, co-Director for the University's LBD Research Center of Excellence, and Director of the Stanford Parkinson’s Foundation Center of Excellence.  Dr. Poston is a Medical Advisor to the Susan and Charles Berghoff Foundation.

RESEARCH IS a WELLSPRING FOR OPTIMISM

Dr. Kathleen Poston on Redefining Parkinson's Disease

This podcast explores advances in detecting the alpha-synuclein pathology behind Parkinson's, Dementia with Lewy bodies, and related neurodegenerative disorders much earlier, even before symptoms arise. Learn how progress is paving the way for early intervention and future prevention.  


In this episode of From Our Neurons to Yours, Nicholas Weiler interviews Dr. Kathleen Poston, a Stanford neurologist at the forefront of efforts to redefine Parkinson's disease and related disorders based on their underlying biology. Dr. Poston brings clarity and insight to this complex topic. 


LISTEN NOW


From Our Neurons to Yours is a podcast of Stanford's Wu Tsai Neurosciences Institute. Podcast logo by Aimee Garza.



UNLOCKING LEWY BODY DISEASE

 

A biological definition of neuronal 

α-synuclein disease: towards an integrated staging system for research


Lancet Neurology, Feb 2024



FDA issues ‘Letter of Support’ for use of synuclein-based biomarker, αSyn-SAA, in clinical trials for Parkinson’s and Related Diseases, including Dementia with lewy bodies


Michael J. Fox Foundation, Sep 2024




 Photo: Al Drago/CQ Roll Call/via Getty Images 



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